A study of renal papillary necrosis rpn

Neither the Commission of the European Communities nor any person acting on behalf of the Commission is responsible for the use which might be made of the information contained in this report. The main objective of the IPCS is to carry out and disseminate evaluations of the effects of chemicals on human health and the quality of the environment. Supporting activities include the development of epidemiological, experimental laboratory, and risk-assessment methods that could produce internationally comparable results, and the development of manpower in the field of toxicology.

A study of renal papillary necrosis rpn

A study of renal papillary necrosis rpn

Blood clots in veins that are located in the kidneys Complete or partial blockage of urine flow in the kidneys Chronic kidney disease When renal papillae die in sufficient numbers, the kidneys become deficient at concentrating urine for its discharge from the body.

In most cases, failure to properly treat RPN results in kidney failure, a life-threatening condition. A person who is inflicted with RPN may exhibit one or more symptoms, some of which may be very serious.

These possible symptoms include: Unusually colored urine dark brown or rust color Blood in the urine Dead tissue in the urine Back pain Pain on one side of the body between the upper abdomen and back Painful urination Frequent urination Urine leakage through the urethra and from the body a condition that is otherwise known as incontinence slide 3 of 5 How Is Renal Papillary Necrosis Diagnosed?

Clinical diagnosis of RPN is very difficult to achieve. In many instances, RPN is diagnosed by performing intravenous urography, a radiological x-ray technique that uses dye to assess whether any abnormalities exist in the kidneys.

In this technique, the presence of RPN in the patient is confirmed if it appears that the dye has accumulated and concentrated at or near the renal papillae.

RPN also can be diagnosed via an imaging method known as computed tomography. These 3D images are more useful that are 2D x-ray images for inspecting the degree to which contrast agents dye concentrate in or near the renal papillae.

A study of renal papillary necrosis rpn

In addition to the imaging methods described above, medical personnel sometimes also perform urinalysis when diagnosing RPN. In this method, urine is inspected by using a battery of physical, chemical, and visual techniques.

Renal papillary necrosis - an overview | ScienceDirect Topics

The observation that tissue or blood is present in the urine serves as further evidence that the patient is suffering from RPN. The typical and best therapeutic course is to treat the underlying condition that has led to RPN in each particular patient. For example, if diabetes is the underlying cause, it is best to focus on treating the diabetes.

Successful treatment of the underlying condition often allows the kidneys to heal over time such that RPN is overcome and no longer problematic.

Biomedical Abbreviations

The main goal of any treatment course that is chosen is to prevent RPN from progressing to the point that kidney failure is experienced. Patients who experience kidney failure must undergo dialysis, in which the patient is attached to a machine that largely serves as an artificial replacement to kidneys by removing waste and fluid from the body, and are at great risk of dying.

This article is meant only to provide some basic information regarding the serious condition known as renal papillary necrosis. It is not meant to replace the good advice of your doctor.Free ebook: Machiavelli's Laboratory "Ethics taught by an unethical scientist" 12, BIOMEDICAL ABBREVIATIONS This page is provided "as is", without warranty of any kind, express or implied, including but not limited to the warranties of merchantability, fitness for .

Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla.


Lesions that characterize renal papillary necrosis come from an impairment of the blood supply and from subsequent ischemic necrosis that is diffuse. Phenacetin and papillary necrosis: Independent risk factors for renal pelvic cancer. A case–control study was undertaken to determine whether renal papillary necrosis (RPN) is an essential step in the genesis of analgesic–associated cancer of the renal .

Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla. Lesions that characterize renal papillary necrosis come from an impairment of the blood supply and from subsequent ischemic necrosis that is diffuse. Renal papillary necrosis Papillary necrosis is a chronic renal injury that has been most commonly associated with long-term analgesic abuse, particularly with phenacetin, From: Textbook of Pediatric Rheumatology (Sixth Edition), Renal papillary necrosis is a condition in which cells of the kidney are damaged, eventually leading to cellular death.

This condition is usually the result of reduced blood flow to the kidneys or.

Renal papillary necrosis - Wikipedia